The Science – Lomelin
Get your free guide

The Science

The Science is simple, two clinically proven active ingredients work together to effectively brighten overall skin appearance and minimize the effects of hyperpigmentation. These ingredients are shown to be effective yet gentle in comparison to some of the other treatments that can cause peeling and burning:

Hyperpigmentation is a common condition in which patches of skin become darker in colour than the surrounding skin. The darkening effect occurs when an excess of melanin, the brown pigment that produces normal skin colour, forms deposits in the skin creating dark spots. Hyperpigmentation may be caused by sun damage, inflammation or other skin injuries. Excess melanin is also produced with hormonal changes, such as during pregnancy and aging, the skin can lose its uniform skin tone forming age spots or a blotchy looking complexion. Individuals with skin of colour are also more prone to hyperpigmentation and even more so with excessive sun exposure.

Lomelin™ will help reduce the appearance of dark spots by suppressing the production of melanin.


Both Alpha Arbutin and Melaslow ingredients have been tested to show safety and tolerability.

5% Melaslow 1

Both Alpha Arbutin and Melaslow ingredients have been tested to show safety and tolerability.

Lightening effect on age spots of caucasian skin

  • 20 Volunteers
  • Application: twice daily for 6 weeks
  • The melanization index fell 28%

Lightening effect on Asian skin

  • 19 Volunteers
  • Application: twice daily for 8 weeks
  • Marked lightening of the complexion as of day 28
  • A highly significant effect was obtained after 56 days.

2% Alpha Arbutin 2

Alpha arbutin reduced cellular tyrosinase to 60% of that in control and decreased cellular content of melanin to 76% of that in non-treated cells. Tyrosinase is a key enzyme in melanin synthesis which in excess causes hyperpigmentation in the epidermis

Alpha arbutin accomplished a reduction in melanin synthesis without affecting cell viability. Research concluded that this ingredient is a safe and effective treatment of skin with hyperpigmentation.


1Melaslow Product Information, Sederma, France

2Sugimoto K, Nishimura T, Nomura K et al. Inhibitory effects of alpha arbutin on melanin synthesis in cultured human melanoma cells and a three-dimensional human skin model. Biol. Pharm. Bull, 2004; ;27(4): 510-514.

Skin Care

17 November 2018
Lomelin Skin Brightening Cream - 30g - $44.99 - with a unique, gentle, non-prescription formulation that combines two natural and proven ingredients, Melaslow - a nature-based citrus peel extract which…
17 November 2018
There are some products on the market that you look at and you have to wonder if they actually work. You WANT them to work, but do they really? More…
03 September 2018
There’s an enormous number of tips and tricks for healthy skin on the internet. To help you sort through the ones that can really make a difference in your complexion,…
03 September 2018
Getting gorgeous skin can be as easy as a walk in the park — literally. Regular exercise — like walking — has been proven to be an effective way to…
Shop Now