2% Alpha Arbutin 2
Alpha arbutin reduced cellular tyrosinase to 60% of that in control and decreased cellular content of melanin to 76% of that in non-treated cells. Tyrosinase is a key enzyme in melanin synthesis which in excess causes hyperpigmentation in the epidermis
Alpha arbutin accomplished a reduction in melanin synthesis without affecting cell viability. Research concluded that this ingredient is a safe and effective treatment of skin with hyperpigmentation.
1Melaslow Product Information, Sederma, France
2Sugimoto K, Nishimura T, Nomura K et al. Inhibitory effects of alpha arbutin on melanin synthesis in cultured human melanoma cells and a three-dimensional human skin model. Biol. Pharm. Bull, 2004; ;27(4): 510-514.